Excipients used in lyophilization of small molecules. The role of excipients such as bulking agents, buffering agents, tonicity modifiers, antimicrobial agents, surfactants and co-solvents has been discussed. Additionally, a decision making process for their incorporation into the formulation matrix has been proposed. The Handbook of Pharmaceutical Excipients can be searched online via MedicinesComplete, providing the most convenient way to explore the wealth of pharmaceutical knowledge available in this resource. Weighted search results and search term guidance direct you to the most appropriate content. Regular online updates ensure the content remains current. No reference work surpasses the Handbook of Pharmaceutical Excipients in the international recognition of the authority of its content and the respect for its editorial board and contributors. “the publisher and editors have once again published an excellent book which has utility for all of us involved in the pharmaceutical industry.”. Paclitaxel is a highly lipophilic drug thus exhibits very poor solubility (10–20 μM) in water. The main limitation in the clinical use of paclitaxel is its poor solubility in aqueous phase and most pharmaceutical solvents. The formulation of paclitaxel used clinically is a mixture containing the excipient, Cremophor EL.
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